By M Sluyser
In apoptosis within the mammalian procedure, cells have a finite existence - they strengthen, are used after which die. melanoma cells get away this programmed regimen yet, from an knowing of apoptosis, they are often programmed to die. This ebook addresses the
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Additional resources for Apoptosis In Normal Development And Cancer
1991) Degradation of cells dying by apoptosis leads to the accumulation of ( -glutamyl)lysine isodipeptide in culture fluid and blood. FEBS Lett. 284, 109–112. , SANTA-CRUZ, G. & PANI, P. (1985) Occurrence of cell death (apoptosis) during the involution of liver hyperplasia. Lab. Invest. 52, 670–679. , FESUS, L. J. (1992) Expression of tissue transglutaminase in Balb-C 3T3 fibroblasts: effects on cellular morphology and adhesion. J. Chem. Biol. 119, 463–474. 1 Introduction Cells in multicellular organisms can kill themselves by activating a suicidal genetic program in response to a wide variety of signals, including hormones, cytokines, ionizing radiation, and chemotherapeutic agents.
1980) Effects of N-tosyl-L-lysyl-chloromethylketone on the activity of cytolytic T lymphocytes. J. Immunol. 124, 1028–1033. 28 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 APOPTOSIS IN NORMAL DEVELOPMENT AND CANCER . , HENGARTNER, H. R. (1988) Structure and function of human perforin. Nature 335, 448–451. , TAKIO, K. & OKUMURA, K. (1988) Homology of perform to the ninth component of complement (C9). Nature 334, 525–527. TSCHOPP, J. & NABHOLZ, M. (1990) Perforin-mediated target cell lysis by cytolytic T lymphocytes.
The appearance of DNA fragments of 300 kb and 50 kb in length in apoptotic cells appears to correspond to cleavage of these loop and rosette structures . Initiation of apoptotic DNA degradation has been proposed [33, 34] to begin with the cleavage of these structures, although it does appear that some cells do not generate the 300 kb fragments . Furthermore, these large fragments have been suggested to provide the substrate for internucleosomal cleavage . While such a scenario is intellectually logical, it should be noted that these conclusions are based solely on data showing that DNA fragmentation into large fragments precedes internucleosomal cleavage.
Apoptosis In Normal Development And Cancer by M Sluyser