Download PDF by M Sluyser: Apoptosis In Normal Development And Cancer

By M Sluyser

ISBN-10: 0203483154

ISBN-13: 9780203483152

ISBN-10: 0748404449

ISBN-13: 9780748404445

In apoptosis within the mammalian procedure, cells have a finite existence - they strengthen, are used after which die. melanoma cells get away this programmed regimen yet, from an knowing of apoptosis, they are often programmed to die. This ebook addresses the

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1991) Degradation of cells dying by apoptosis leads to the accumulation of ( -glutamyl)lysine isodipeptide in culture fluid and blood. FEBS Lett. 284, 109–112. , SANTA-CRUZ, G. & PANI, P. (1985) Occurrence of cell death (apoptosis) during the involution of liver hyperplasia. Lab. Invest. 52, 670–679. , FESUS, L. J. (1992) Expression of tissue transglutaminase in Balb-C 3T3 fibroblasts: effects on cellular morphology and adhesion. J. Chem. Biol. 119, 463–474. 1 Introduction Cells in multicellular organisms can kill themselves by activating a suicidal genetic program in response to a wide variety of signals, including hormones, cytokines, ionizing radiation, and chemotherapeutic agents.

1980) Effects of N-tosyl-L-lysyl-chloromethylketone on the activity of cytolytic T lymphocytes. J. Immunol. 124, 1028–1033. 28 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 APOPTOSIS IN NORMAL DEVELOPMENT AND CANCER . , HENGARTNER, H. R. (1988) Structure and function of human perforin. Nature 335, 448–451. , TAKIO, K. & OKUMURA, K. (1988) Homology of perform to the ninth component of complement (C9). Nature 334, 525–527. TSCHOPP, J. & NABHOLZ, M. (1990) Perforin-mediated target cell lysis by cytolytic T lymphocytes.

The appearance of DNA fragments of 300 kb and 50 kb in length in apoptotic cells appears to correspond to cleavage of these loop and rosette structures [34]. Initiation of apoptotic DNA degradation has been proposed [33, 34] to begin with the cleavage of these structures, although it does appear that some cells do not generate the 300 kb fragments [34]. Furthermore, these large fragments have been suggested to provide the substrate for internucleosomal cleavage [33]. While such a scenario is intellectually logical, it should be noted that these conclusions are based solely on data showing that DNA fragmentation into large fragments precedes internucleosomal cleavage.

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Apoptosis In Normal Development And Cancer by M Sluyser


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