By Mahmoud Ghannoum, Mahmoud A. Ghannoum, John R. Perfect MD, John R. Perfect
A concise one-stop-practical reference for many of the physicians facing fungal infections, Antifungal remedy appeals to infectious affliction physicians, transplant surgeons, dermatologists, and intensivists, in addition to simple scientists and pharmaceutical corporation researchers drawn to the country of antifungal treatment. This ebook presents a finished, up to date evaluation of the pertinent concerns touching on antifungal therapy. Divided into 4 interrelated sections for a cohesive dialogue covers:
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In a nonendemic area, the absence of clinical suspicion along with lack of detailed information about the donor, such as travel history, may lead to a delay in diagnosis. In contrast to SOT, coccidioidomycosis in BMT recipients has not been widely reported, even in endemic areas. In a retrospective review of autologous recipients, the low incidence was attributed to possible underreporting of disease and possibly reduced sensitivity of coccidioidal serology in patients with malignancy (294). Histoplasma Two varieties of Histoplasma may cause disease in humans: Histoplasma capsulatum var.
Early recognition and prompt treatment are therefore crucial to avoid mortality in miliary coccidioidomycosis, and a high index of suspicion is important because early in the course of illness, skin test results are negative, and serology is unrevealing. EPIDEMIOLOGY OF FUNGAL INFECTIONS: WHAT, WHERE, AND WHEN 23 Coccidioides fungemia has been rarely reported, and of 33 adult reported cases, 31 were male and 29 were seropositive for HIV (281). Seventy-four percent of patients died during the admission or shortly thereafter, with a mean survival of only eight days.
Albicans was the most common species recovered, accounting for 54% of cases, followed by C. glabrata (19%), C. parapsilosis 26 COSTA AND ALEXANDER (11%), C. tropicalis (11%), and C. krusei (2%) (341). A similar distribution was reported from a separate National Nosocomial Infections Surveillance (NNIS) investigation that only included ICUs (342). In neonatal ICUs, the distribution seems to be slightly different in that C. parapsilosis is typically the second most commonly isolated species rather than C.
Antifungal Therapy by Mahmoud Ghannoum, Mahmoud A. Ghannoum, John R. Perfect MD, John R. Perfect