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By Novartis Foundation symposium on Anaphylaxis

ISBN-10: 0470861142

ISBN-13: 9780470861141

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When you have cohorts which you are Th2 ANTIBODIES AND ALLERGY 41 following up for a long time, it is enormously powerful to have the correlation of immunology with clinical patterns. Vercelli: I couldn’t agree more.

Simons: I would like to comment on the issue of diagnosis. Johannes Ring mentioned that diagnosis of anaphylaxis is easy. However, I’d like to suggest that there is at least one group of patients in whom this isn’t the case, namely infants and pre-school children. I was concerned for many years by the fact that few infants and young children were included in the retrospective studies of anaphylaxis episodes from all triggers in all ages that have been published (Yocum et al 1999, Kemp et al 1995).

Perhaps at this point such detailed comparative studies of the systemic and the local antibody have not been done. Gould: The amount of information is perhaps limited, but as I have said before we have shown in our work with hay fever patients that the ratio of speci¢c to total IgE is signi¢cantly greater in the IgE produced in the nasal mucosa than in serum IgE, and in some patients we could only detect speci¢c IgE as a product of local IgE synthesis (Smurthwaite et al 2001). There is also the earlier evidence that in some patients IgE antibodies against allergens are undetectable in serum but detectable in nasal secretions (reviewed in Durham et al 1997).

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Anaphylaxis by Novartis Foundation symposium on Anaphylaxis


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