By John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. Michael I. Lethem (eds.)
Conceptually unsavoury, airway mucus is essential to homeostasis within the respiration tract. against this, whilst irregular, mucus contributes considerably to the pathophysiology of a few serious bronchial ailments, together with bronchial asthma, persistent bronchitis and cystic fibrosis. This quantity offers large ranging and in-depth insurance of the clinical and medical facets of airway mucus. It commences with introductory chapters which deal with the biochemical and molecular organic foundation of airway mucus and keeps with accomplished assurance of a few of the physiological and rheological facets of respiration secretions. The medical points of the subject are then thought of, with chapters discussing the involvement of mucus secretions in bacterial an infection and in hypersecretory illnesses of the airway. the quantity concludes with a dialogue of the healing points of the subject, either by way of the potential ways to the remedy of mucus hypersecretion and the interplay of those medicinal drugs with airway mucus. Written via prime specialists within the box, every one contribution offers a entire overview of its specific topic. Reflecting the newest advances during this vital quarter of respiration study, this quantity can be of serious curiosity to scientists and clinicians operating within the box of airway secretions and similar areas.
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Additional info for Airway Mucus: Basic Mechanisms and Clinical Perspectives
20. Gendler S, Lancaster CA, Tylor-Papidimitriou J, Duhig T, Peat N, Burchell J, Pemberton L, Lalani E-N, Wilson D (1990) Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J Bioi Chem 265: 15286-15293. 21. Lightenberg MJL, Vos HL, Gennissen AMC, Hilkens J. Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini. J Bioi Chem 265: 5573-5578. 22. Gum JR, Byrd JC, Hicks JW, Toribara NW, Lamport DTA, Kim YS (1989) Molecular cloning of human intestinal cDNAs.
Phenotypic analysis of mucins, will be an important step in unraveling the roles of specific mucins in health and disease. This task will be complicated if specific domains in each MUC backbone (Figure 2) have different O-glycosylation determinants. For example, one of the four major Table 2. '" r«/////AI I10'/ AI V///U//Z11 V v I . > ,~~'\ I MUCS MUC7' MUC 6 MUC58 MUC5AC MUC 4 MUC3 MUC2' MUC l' Figure 2. Models of MUC primary structures deduced from nucleotide sequences of completed MUC genes (*) or cDNA clones.
Vishwanath S, Ramphal R (1985) Tracheobronchial mucin receptor for Pseudomonas aeruginosa: Predominance of amino sugars in binding sites. Infect Immun 48: 331-335. 80. Coles SJ, Reid LM (1978) Glycoprotein secretion in vitro by human airway: Normal and chronic bronchitis. Exp Molec Pathol29: 326-341. 81. Phipps RJ, Williams IP, Richardson PS, Pell J, Pack RJ, Wright N (1982) Sympathomimetic drugs stimulate the output of secretory glycoproteins from human bronchi in vitro. Clin Sci 63: 23-28. 82.
Airway Mucus: Basic Mechanisms and Clinical Perspectives by John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. Michael I. Lethem (eds.)