Download PDF by Gilbert N. Ling: A Revolution in the Physiology of the Living Cell

By Gilbert N. Ling

ISBN-10: 0894643983

ISBN-13: 9780894643989

The essence of an immense revolution in mobilephone body structure -- the 1st because the cellphone used to be well-known because the simple unit of lifestyles a century and a part in the past -- is gifted and replacement theories are mentioned during this textual content. even if the traditional membrane-pump concept continues to be being taught, one other thought of the residing mobile, referred to as the association-induction speculation, has been proposed. It has effectively withstood twenty-five years of globally checking out and has already generated an improving diagnostic device of serious energy, magnetic resonance imaging (MRI). This quantity is meant for academics, scholars and researchers of biology and medication.

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Assuming further that the cell required energy only for the pumping of Naf , and that all energy utilization and transfer processes were 10 0 % efficient, the minimum energy needed by the Na pump at the plasma membrane alone was from 1542% to 3050% of the maximum available energy (Ling 1962, Chapter 8). 8 Rcal/mole of utilizable free energy in its phosphate bonds. Compelling evidence to be described in the next section indicates that in the phosphate bonds of ATP, ADP, or CrP there is no readily utilizable free energy.

S. Lillie reasoned that K+ accumulation in cells could not be due to binding. 3)] or some active physiological f actor is at work which opposes or compensates for the ef fect of diffusion . . ” (Lillie 1923, 117). Strangely, it is Robert Dean who has become widely quoted as the founder of the Na Pump Hypothesis. However, his advocacy was neither original nor en­ thusiastic, nor was it backed by extensive original work of his own on the subject. Rejecting the selective K+ accumulation in, and Na+ exclusion from cells as a result of different permeabilities of the cell membranes to K+ and Na+ in dif­ ferent directions— which Dean correctly pointed out was a “Maxwellian demon”1 and not acceptable— Dean concluded his writing on “The Pump Theory" in these words: “It is safer to assume that there is a pump of unknown mechanism which is doing work at a constant rate excreting sodium as fast as it diffuses into the cell” (Dean 1941, 346).

Another set of rules is that the equilibrium concentration of a permeant ion bearing the same charge as the impermeant ion is lower on the side containing the impermeant ion, while the concentration o f permeant ion bearing the opposite charge as the impermeant ion is higher on the side containing the impermeant ion. That the living cells may represent a system that follows Donnan’s concept of membrane equilibrium was of ten advocated (see Netter, 1928). T h ere was at one time also the belief that proteins provide the impermeant anions essential for the establishment of such a system.

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A Revolution in the Physiology of the Living Cell by Gilbert N. Ling


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