By D. G. Cunningham Owens
Antipsychotic medications have revolutionized the administration of significant psychiatric issues and the results of these that suffer from them. although, they generally give a contribution to quite a number opposed results, one of the such a lot common and distressing of that are these leading to disturbance of voluntary motor functionality. Extrapyramidal part effects--or EPS--are nonetheless poorly well-known and regularly misattributed. regardless of enormous examine literature, there were few makes an attempt to assemble either the descriptive scientific parts of those issues and significant study conclusions pertinent to regimen perform. This very readable and well-illustrated booklet seeks to rectify this challenge within the desire of accelerating clinicians' know-how of the problems and acknowledgement in their impression. it is a activity made tougher through the emergence of latest medicinal drugs with reduce legal responsibility that could advertise subtler abnormalities than common compounds. This publication might be an incredible reference for psychiatrists, neurologists, and different clinicians who prescribe antipsychotic medicinal drugs.
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Extra info for A Guide to the Extrapyramidal Side Effects of Antipsychotic Drugs
It is interesting how successful doctors can be at presenting compliance as largely, if not exclusively, a patient-based issue. When compliance breaks down, it is invariably portrayed as the patient’s ‘fault’. This is a cop-out. Doctors, by their recommendations, can impact on many of the factors that contribute to poor compliance, for example by simplifying regimes to something the average individual has a fighting chance of remembering, by taking time to explain the nature and purpose of treatment, and, most importantly, by recognising side-effects when they develop, acknowledging their importance and, where possible, intervening to alleviate them.
It is therefore not surprising that this drug can be associated with the development of EPS and in particular tardive dyskinesia (Lapierre and Anderson, 1983). Of interest, however, is the evidence that has started to accrue in recent years that the selective serotonin re-uptake inhibitors (SSRIs) may cause extrapyramidal dysfunction. , 1993; Arya, 1994). The most frequently implicated agent has been fluoxetine, but this probably reflects nothing more than this drug’s widespread use, particularly in the USA, from where most case reports have emanated.
Thus, an amateur chemist with an illicit still and a mission to alter minds unwittingly altered medical research instead by opening a whole new door on one of medicine’s great mysteries. He may further have shed light on the mechanism of the parkinsonism very occasionally encountered with the narcotic analgesic pethidine (meperidine) which may result from formation of MPTP. Finally, there is, as always, alcohol. The association here is not, for once, a positive one but more, as it were, a ‘negative’ one.
A Guide to the Extrapyramidal Side Effects of Antipsychotic Drugs by D. G. Cunningham Owens